An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis

LaMarche N, Hegde S, Park M, Maier B, Troncoso L, Le Berichel J, Hamon P, Belabed M, Mattiuz R, Hennequin C, Chin T, Reid A, Reyes-Torres I, Nemeth E, Zhang R, Olson O, Doroshow D, Rohs N, Gomez J, Veluswamy R, Hall N, Venturini N, Ginhoux F, Liu Z, Buckup M, Figueiredo I, Roudko V, Miyake K, Karasuyama H, Gonzalez-Kozlova E, Gnjatic S, Passegué E, Kim-Schulze S, Brown B, Hirsch F, Kim B, Marron T, Merad M.
Nature 2023, 625: 166-174. PMID: 38057662, DOI: 10.1038/s41586-023-06797-9

Peer-Reviewed Original Research

Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis.

LaMarche NM, Kane H, Kohlgruber AC, Dong H, Lynch L, Brenner MB.
Cell Metabolism 2020, 32: 243-258.e6. PMID: 32516575, DOI: 10.1016/j.cmet.2020.05.017.

Peer-Reviewed Original Research

2023

TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer.

Park MD, Reyes-Torres I, LeBerichel J, Hamon P, LaMarche NM, Hegde S, Belabed M, Troncoso L, Grout JA, Magen A, Humblin E, Nair A, Molgora M, Hou J, Newman JH, Farkas AM, Leader AM, Dawson T, D'Souza D, Hamel S, Sanchez-Paulete AR, Maier B, Bhardwaj N, Martin JC, Kamphorst AO, Kenigsberg E, Casanova-Acebes M, Horowitz A, Brown BD, De Andrade LF, Colonna M, Marron TU, Merad M.
J Nature Immunology 2023, 24: 792-801. PMID: 37081148, DOI: 10.1038/s41590-023-01475-4.

Peer-Reviewed Original Research